Relative adrenal insufficiency in mice deficient in 5α-reductase 1
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Relative adrenal insufficiency in mice deficient in 5α-reductase 1
Patients with critical illness or hepatic failure exhibit impaired cortisol responses to ACTH, a phenomenon known as 'relative adrenal insufficiency'. A putative mechanism is that elevated bile acids inhibit inactivation of cortisol in liver by 5α-reductases type 1 and type 2 and 5β-reductase, resulting in compensatory downregulation of the hypothalamic-pituitary-adrenal axis and adrenocortical...
متن کاملExplorer Relative adrenal insufficiency in mice deficient in 5 - reductase 1
Patients with critical illness or hepatic failure exhibit impaired cortisol responses to ACTH, a phenomenon known as ‘relative adrenal insufficiency’. A putative mechanism is that elevated bile acids inhibit inactivation of cortisol in liver by 5a-reductases type 1 and type 2 and 5b-reductase, resulting in compensatory downregulation of the hypothalamic–pituitary– adrenal axis and adrenocortica...
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Relative adrenal insufficiency (RAI) was demonstrated in patients with cirrhosis and liver failure. A relationship appears to exist between the severity of the liver disease and the presence of RAI. Neither the mechanism nor the exact prevalence of RAI is fully understood. There is though a hypothesis that low high-density lipoprotein (HDL) levels in this group of patients may be responsible fo...
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Androgens are important regulators of bone mass but the relative importance of testosterone (T) versus dihydrotestosterone (DHT) for the activation of the androgen receptor (AR) in bone is unknown. 5α-reductase is responsible for the irreversible conversion of T to the more potent AR activator DHT. There are two well established isoenzymes of 5α-reductase (type 1 and type 2), encoded by separat...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2014
ISSN: 0022-0795,1479-6805
DOI: 10.1530/joe-13-0563